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Temporospatial cell interactions regulating mandibular and maxillary arch patterning.

C A Ferguson1, A S Tucker, P T Sharpe

  • 1Department of Craniofacial Development, GKT Dental Institute, Kings College, Guy's Hospital, London SE1 9RT, UK.

Development (Cambridge, England)
|December 22, 1999
PubMed
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Jaw patterning is instructed by oral epithelium, not pre-specified cells. Epithelial signals induce gene expression in mandibular ectomesenchyme, with differences emerging between jaw types over time.

Area of Science:

  • Developmental Biology
  • Craniofacial Development
  • Epithelial-Mesenchymal Interactions

Background:

  • The cellular origin of jaw hard tissue patterning is debated, questioning whether cranial neural crest cells are prepatterned or instructed by epithelium.
  • Understanding orofacial patterning control requires investigating temporal signaling between oral epithelium and mesenchymal cells.

Purpose of the Study:

  • To investigate temporal signaling interactions and responses between epithelium and mesenchymal cells in mandibular and maxillary primordia.
  • To determine the role of epithelial signals in inducing homeobox gene expression in ectomesenchymal cells during jaw development.

Main Methods:

  • Analysis of homeobox gene expression in mandibular and maxillary primordia at different developmental stages (E10, E10.5, E11) in mice.

Related Experiment Videos

  • Experimental manipulation including epithelial removal and reciprocal cell transplantation between mandibular and maxillary arch ectomesenchymal cells.

    • Main Results:

    • Epithelial signals induce homeobox gene expression in mandibular ectomesenchyme, indicating a lack of pre-specification before E10.
    • Ectomesenchymal gene expression domains become fixed and dependent on epithelial signals by E10.5, but independent by E11.
    • Mandibular and maxillary epithelia exhibit distinct instructive signaling properties, with neither inducing Dlx5 expression in the maxilla, suggesting intrinsic differences in ectomesenchymal cells.

    Conclusions:

    • Jaw hard tissue patterning, particularly in the mandible, is instructed by the oral epithelium.
    • Intrinsic differences exist between mandibular and maxillary ectomesenchymal cells, influencing their response to epithelial signals.
    • Jaw-specific skeletal development may involve prespecification of maxillary ectomesenchyme to ensure distinct maxillary structure formation.