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Related Experiment Videos

Intermittent catheterization limits rabbit bladder dysfunction in response to partial outlet obstruction.

N Ohnishi1, P Horan, S S Levin

  • 1Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, New York 12208, USA.

The Journal of Urology
|December 22, 1999
PubMed
Summary
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Limiting bladder distension with intermittent catheterization (IntCath) in rabbits reduced bladder mass, improved elasticity, and preserved contractile function following urinary outflow obstruction. This intervention protects the bladder from decompensation.

Area of Science:

  • Urology
  • Physiology
  • Biomedical Engineering

Background:

  • Urinary bladder outflow obstruction leads to distension, mass increase, and functional decline (decompensation).
  • Understanding mechanisms of bladder decompensation is crucial for developing protective strategies.
  • Intermittent catheterization (IntCath) was explored as a method to limit bladder distension.

Purpose of the Study:

  • To investigate if limiting bladder distension via IntCath can prevent or mitigate bladder decompensation caused by outflow obstruction.

Main Methods:

  • Male New Zealand White rabbits underwent 14 days of bladder outflow obstruction, with some receiving IntCath.
  • Bladder mass, compliance, and contractile responses to various stimuli (field stimulation, KCl, ATP, carbachol) were measured.

Related Experiment Videos

  • Groups included: control, control with IntCath, obstructed, and obstructed with IntCath.

    • Main Results:

    • IntCath did not affect control bladders.
    • Obstruction significantly increased bladder weight and decreased compliance and contractile function.
    • IntCath significantly reduced the increase in bladder mass and preserved compliance and contractile responses compared to obstructed bladders without IntCath.

    Conclusions:

    • Limiting bladder distension using IntCath effectively reduces bladder mass increase, preserves bladder wall elasticity, and improves contractile function after obstruction.
    • IntCath shows potential as a protective intervention against the detrimental effects of urinary outflow obstruction.