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[Local corticosteroid therapy in dermatology].
O Chosidow1, B Lebrun-Vignes, I Bourgault-Villada
1Service de Médecine interne, Groupe Hospitalier Pitié-Salpêtrière, Paris. olivier.chosidow@psl.ap-hop-paris.fr
Presse Medicale (Paris, France : 1983)
|December 22, 1999
Summary
Topical corticosteroids, or dermocorticosteroids, offer potent anti-inflammatory effects for various skin conditions. Proper selection and application are crucial, considering disease factors and patient characteristics for optimal outcomes.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Dermocorticosteroids (corticosteroids for topical application) have significantly advanced the management of numerous skin diseases.
- These agents possess anti-inflammatory, vasoconstrictor, antiproliferative, antisynthetic, and immunosuppressive properties.
Purpose of the Study:
- To outline the classification, properties, and application guidelines for dermocorticosteroids.
- To provide a comprehensive overview of their indications, contraindications, and factors influencing efficacy.
Main Methods:
- Review of the pharmacological actions of dermocorticosteroids.
- Analysis of factors influencing skin penetration, including drug properties and application methods.
- Compilation of established indications and contraindications for topical corticosteroid use.
Main Results:
- Dermocorticosteroids are classified into four levels based on anti-inflammatory potency.
- Skin penetration is influenced by drug characteristics, excipients, occlusion, and patient-specific factors.
- Effective for inflammatory dermatoses like psoriasis and eczema, but contraindicated in infections, acne, and rosacea.
Conclusions:
- Selection of an appropriate dermocorticosteroid requires consideration of disease sensitivity, extent, location, patient age, and treatment duration.
- Creams offer cosmetic benefits, and the quantity used must be controlled.
- Occlusion is recommended for palmar, plantar, or scalp conditions.