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Updated: Aug 14, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Striking increase of thin melanomas contrasts with stable incidence of thick melanomas
D M Lipsker1, G Hedelin, E Heid
1Laboratoire d'Histopathologie Cutanée, Clinique Dermatologique, Strasbourg, France. dlipsker@cybercable.fr
Objective:
The aim of this study was to analyze the temporal evolution of melanoma incidence in the department of the Bas-Rhin, France, and to study the evolution of tumor thickness.
Design:
Retrospective study including all histologically proven melanomas recorded at the cancer registry of the department of the Bas-Rhin between January 1980 and December 1992 and at the Cutaneous Histopathology Department of the University Hospitals, Strasbourg, between January 1980 and December 1997.
Setting:
Population-based cancer registry and academic cutaneous histopathology department.
Patients:
A total of 1254 patients with histologically proven melanomas.
Intervention:
None.
Main Outcome Measures:
Temporal evolution of melanoma incidence and tumor thickness.
Results:
The mean (SD) and median tumor thicknesses were 1.48 (1.59) mm and 0.87 mm, respectively, and they decreased during the study period. The increase in the number of melanomas was mainly related to an increase of superficial spreading melanomas in both sexes. The number of intermediate melanomas (1-2 mm) in both sexes and the number of melanomas with a Breslow index between 2 and 4 mm in women increased only slightly. The number of melanomas with a Breslow index greater than 2 mm in men and greater than 4 mm in women remained stable during the reference period.
Conclusion:
A striking increase in incidence of thin melanomas contrasts with a stable incidence of thick melanomas.
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