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Related Experiment Videos

AILIM/ICOS: a novel lymphocyte adhesion molecule.

T Tamatani1, K Tezuka, N Hanzawa-Higuchi

  • 1Pharmaceutical Frontier Research Laboratories, JT Inc., 1-13-2 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

International Immunology
|December 23, 1999
PubMed
Summary

A novel rat adhesion molecule, AILIM (Inducible co-stimulator homolog), functions in T cell activation. It mediates cell adhesion and aggregation, highlighting its role in forming the immunological synapse and T cell responses.

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Area of Science:

  • Immunology
  • Cell Adhesion Biology

Background:

  • The formation of the immunological synapse between T cells and antigen-presenting cells relies on adhesive interactions.
  • Inducible co-stimulator (ICOS) is a co-stimulatory molecule within the CD28 family, crucial for T cell responses.

Purpose of the Study:

  • To identify and characterize a novel lymphocyte adhesion molecule in rats.
  • To investigate the function of this molecule, a homolog of ICOS, in T cell activation and adhesion.

Main Methods:

  • Identification and characterization of a novel rat lymphocyte adhesion molecule, designated AILIM.
  • Analysis of AILIM expression on thymocytes and naive T cells post-activation.
  • Binding assays using purified AILIM and human thymoma cells.
  • Gene transfection experiments to assess AILIM-dependent cell aggregation.

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Main Results:

  • A novel rat adhesion molecule, AILIM (47,000 relative molecular mass), was identified as a homolog of ICOS.
  • AILIM was constitutively expressed on thymocytes and induced on naive T cells upon activation.
  • Purified AILIM bound to human thymoma cells, and AILIM-transfected cells exhibited aggregation in an AILIM-dependent manner.

Conclusions:

  • AILIM functions as a lymphocyte adhesion molecule.
  • AILIM/ICOS plays a significant role in T cell activation and immunological synapse formation.