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Related Experiment Videos

Plexiform spitz nevus: an intradermal spitz nevus with plexiform growth pattern.

A Spatz1, S Peterse, C D Fletcher

  • 1Department of Pathology, Institut Gustave-Roussy, Villejuif, France.

The American Journal of Dermatopathology
|December 23, 1999
PubMed
Summary

This study describes a unique variant of Spitz nevus, termed "plexiform Spitz nevus," characterized by a distinctive growth pattern. This finding aids in distinguishing it from other skin tumors.

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Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Spitz nevi are typically benign melanocytic neoplasms.
  • A distinctive variant with a plexiform growth pattern is presented.

Observation:

  • Two cases of plexiform Spitz nevus occurred in a 17-year-old boy and a 52-year-old man.
  • Microscopic examination revealed enlarged spindle to epithelioid melanocytes in a plexiform arrangement within the dermis.
  • Features included myxoid stroma, multinucleate giant cells, and strong S-100 immunoreactivity, with no HMB-45 positivity.

Findings:

  • The described variant exhibits a unique plexiform growth pattern, differentiating it from classical Spitz nevi.
  • Immunohistochemistry showed strong S-100 reactivity, aiding in differential diagnosis.
  • Absence of significant mitoses and melanin pigment was noted.

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Implications:

  • The term "plexiform Spitz nevus" is proposed to highlight its distinct histological features.
  • Accurate diagnosis is crucial for differentiating this entity from malignant melanomas.
  • This classification aids dermatopathologists in managing melanocytic lesions.