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A Canadian guideline on the use of next-generation sequencing in oncology
S Yip1, A Christofides2, S Banerji3
1Cancer Genetics and Genomics Lab, BC Cancer, Vancouver, BC.
Abstract:
Rapid advancements in next-generation sequencing (ngs) technology have created an unprecedented opportunity to decipher the molecular profile of tumours to more effectively prevent, diagnose, and treat cancer. Oncologists now have the option to order molecular tests that can guide treatment decisions. However, to date, most oncologists have received limited training in genomics, and they are now faced with the challenge of understanding how such tests and their interpretation align with patient management. Guidance on how to effectively use ngs technology is therefore needed to aid oncologists in applying the results of genomic tests. The Canadian guideline presented here describes best practices and unmet needs related to ngs-based testing for somatic variants in oncology, including clinical application, assay and sample selection, bioinformatics and interpretation of reports performed by laboratories, patient communication, and clinical trials.
Insights
Next-generation sequencing (NGS) offers powerful cancer insights, but oncologists need genomic training. This guideline provides best practices for using NGS tests in oncology to improve patient care.
Area of Science:
- Oncology
- Genomics
- Molecular Diagnostics
Background:
- Next-generation sequencing (NGS) technology advances cancer molecular profiling for improved prevention, diagnosis, and treatment.
- Molecular tests are available to guide cancer treatment decisions, but oncologists often lack sufficient genomics training.
- Understanding the clinical application of NGS test results for patient management presents a challenge.
Purpose of the Study:
- To provide guidance for oncologists on the effective use of NGS technology in cancer care.
- To outline best practices and identify unmet needs for NGS-based testing for somatic variants in oncology.
- To support the integration of genomic test results into clinical decision-making.
Main Methods:
- Development of a Canadian guideline based on expert consensus and literature review.
- Inclusion of key areas: clinical application, assay/sample selection, bioinformatics, interpretation, patient communication, and clinical trials.
- Focus on somatic variants in oncology.
Main Results:
- The guideline addresses practical aspects of implementing NGS in clinical oncology settings.
- Identifies areas where further development and standardization are needed.
- Provides a framework for interpreting and applying NGS results for patient management.
Conclusions:
- Effective utilization of NGS requires enhanced oncologist training in genomics.
- Standardized guidelines are crucial for consistent and accurate application of NGS in cancer diagnostics and treatment.
- This guideline aims to bridge the gap between genomic testing capabilities and clinical oncology practice.
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