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Soft drug design: general principles and recent applications.

N Bodor1, P Buchwald

  • 1Center for Drug Discovery, University of Florida, Health Science Center, P.O. Box 100497, Gainesville, Florida 32610-0497, USA. bodor@cop.ufl.edu

Medicinal Research Reviews
|December 23, 1999
PubMed
Summary

Soft drug design creates safer medications by predicting metabolism for controlled deactivation. This approach enhances the therapeutic index by integrating metabolic strategies early in drug development.

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Area of Science:

  • Pharmacology
  • Medicinal Chemistry
  • Drug Design

Background:

  • Soft drug design integrates metabolism into drug development for enhanced safety.
  • This approach yields therapeutic agents that predictably metabolize into inactive forms post-effect.

Purpose of the Study:

  • To review general principles of soft drug design.
  • To provide examples of successful soft drug applications and ongoing research.

Main Methods:

  • Systematic review of laboratory work on soft drug design.
  • Illustrative examples of soft drug candidates and marketed drugs.

Main Results:

  • Successful application of soft drug principles in marketed drugs like esmolol, remifentanil, and loteprednol etabonate.

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  • Numerous promising soft drug candidates are under investigation across various therapeutic areas.

    • Conclusions:

    • Soft drug design offers a viable strategy for developing safer drugs with improved therapeutic indices.
    • The principles of soft drug design are applicable to a wide range of therapeutic agents, with ongoing research showing significant potential.