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Does axillary dissection affect prognosis in T1 breast tumors?
C E Dimitrakakis1, M M Konstadoulakis, G D Kymionis
1Department of Surgery, Hippokration Hospital, Athens Medical School, Greece.
European Journal of Gynaecological Oncology
|December 28, 1999
Summary
Axillary lymph node dissection (ALND) did not impact survival rates for T1 breast cancer patients. Tumor size emerged as the sole independent prognostic factor, influencing both survival and recurrence.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Evolving trends in breast cancer treatment favor breast conservation and limited resections.
- The role of axillary lymph node dissection (ALND) in early-stage breast cancer is debated, particularly its prognostic significance for small tumors.
Purpose of the Study:
- To evaluate the impact of axillary lymph node dissection (ALND) on survival and recurrence rates in patients with T1 invasive breast carcinoma.
- To identify independent prognostic factors for T1 breast cancer.
Main Methods:
- Retrospective chart review of 100 T1 invasive breast carcinoma patients treated between 1986-1987.
- Comparison of outcomes between patients who underwent ALND (n=76) and those who did not (n=24).
- Analysis of ten-year overall and disease-free survival, with univariate and multivariate analyses to identify prognostic variables.
Main Results:
- No statistically significant difference in ten-year overall or disease-free survival between groups with and without ALND.
- Tumor size was identified as a predictor of recurrence and survival in univariate analysis.
- Multivariate analysis confirmed tumor size as an independent prognostic factor for overall survival.
Conclusions:
- Axillary lymph node dissection (ALND) does not influence ten-year survival or recurrence rates in T1 breast cancer.
- Tumor size is the only statistically significant and independent prognostic factor for T1 breast cancer patients.