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HLA and Mooren's ulceration.

C J Taylor1, S I Smith, C H Morgan

  • 1Addenbrooke's University Hospital NHS Trust, Cambridge.

The British Journal of Ophthalmology
|December 28, 1999
PubMed
Summary
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Mooren's ulcer, a rare autoimmune corneal disease, shows a strong association with specific human leucocyte antigen (HLA) types. This genetic link, particularly with HLA-DR17(3) and HLA-DQ2, may explain the disease's predisposition in certain populations.

Area of Science:

  • Ophthalmology
  • Immunogenetics

Background:

  • Mooren's ulcer is a rare, progressive, destructive peripheral corneal ulcer of likely autoimmune origin.
  • It predominantly affects specific ethnic groups and their descendants, suggesting a genetic predisposition.
  • Human leucocyte antigens (HLA) are known to confer susceptibility to autoimmune disorders.

Purpose of the Study:

  • To investigate a potential association between human leucocyte antigen (HLA) types and Mooren's ulcer.
  • To explore the genetic factors contributing to Mooren's ulcer susceptibility.

Main Methods:

  • Recruited 22 patients with non-infective destructive peripheral corneal inflammatory disease.
  • Diagnosed Mooren's ulcer in 12 cases through differential diagnosis.
  • Performed HLA typing (HLA-A, B, C, DRB, DQB) using serology and PCR, comparing results with ethnically matched controls.

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Main Results:

  • 10 out of 12 Mooren's ulcer patients (83%) were positive for HLA-DR17(3).
  • 10 out of 12 Mooren's ulcer patients (83%) were positive for HLA-DQ2.
  • Frequencies of HLA-DR17(3) and DQ2 were significantly higher in Mooren's ulcer patients compared to controls.

Conclusions:

  • Suggests a possible association between HLA-DR17(3) and/or HLA-DQ2 and susceptibility to Mooren's ulcer.
  • Highlights the role of specific HLA types in the genetic predisposition to this rare autoimmune eye disease.