Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and Mooren's ulceration.

C J Taylor1, S I Smith, C H Morgan

  • 1Addenbrooke's University Hospital NHS Trust, Cambridge.

The British Journal of Ophthalmology
|December 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Mixed-methods Study of How to Improve Primary-secondary Transitions in England: Combining Academic Research with Policy and Practice Consultation.

Educational psychology review·2026
Same author

Range-resolved water temperature measurement using Raman LiDAR with multiplexed excitation.

Optics express·2026
Same author

Observation of a mixed close-packed structure in superionic water.

Nature communications·2025
Same author

Loop diuretics, heart failure diagnosis and outcome in primary care.

International journal of cardiology·2025
Same author

Depth-resolved water temperature measurements using Raman LiDAR.

Applied optics·2024
Same author

An Overview of the Impact of the Covid-19 Pandemic on the Provision of Palliative Care.

Irish medical journal·2023
Same journal

Identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning.

The British journal of ophthalmology·2026
Same journal

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

The British journal of ophthalmology·2026
Same journal

Reference map of multimodal vision deficits in intermediate age-related macular degeneration: contrast sensitivity and low-contrast visual acuity.

The British journal of ophthalmology·2026
Same journal

Commentary on 'identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning'.

The British journal of ophthalmology·2026
Same journal

Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

The British journal of ophthalmology·2026
Same journal

Bacterial keratitis: a global review of current practices, challenges and innovations.

The British journal of ophthalmology·2026
See all related articles

Mooren's ulcer, a rare autoimmune corneal disease, shows a strong association with specific human leucocyte antigen (HLA) types. This genetic link, particularly with HLA-DR17(3) and HLA-DQ2, may explain the disease's predisposition in certain populations.

Area of Science:

  • Ophthalmology
  • Immunogenetics

Background:

  • Mooren's ulcer is a rare, progressive, destructive peripheral corneal ulcer of likely autoimmune origin.
  • It predominantly affects specific ethnic groups and their descendants, suggesting a genetic predisposition.
  • Human leucocyte antigens (HLA) are known to confer susceptibility to autoimmune disorders.

Purpose of the Study:

  • To investigate a potential association between human leucocyte antigen (HLA) types and Mooren's ulcer.
  • To explore the genetic factors contributing to Mooren's ulcer susceptibility.

Main Methods:

  • Recruited 22 patients with non-infective destructive peripheral corneal inflammatory disease.
  • Diagnosed Mooren's ulcer in 12 cases through differential diagnosis.
  • Performed HLA typing (HLA-A, B, C, DRB, DQB) using serology and PCR, comparing results with ethnically matched controls.

Related Experiment Videos

Main Results:

  • 10 out of 12 Mooren's ulcer patients (83%) were positive for HLA-DR17(3).
  • 10 out of 12 Mooren's ulcer patients (83%) were positive for HLA-DQ2.
  • Frequencies of HLA-DR17(3) and DQ2 were significantly higher in Mooren's ulcer patients compared to controls.

Conclusions:

  • Suggests a possible association between HLA-DR17(3) and/or HLA-DQ2 and susceptibility to Mooren's ulcer.
  • Highlights the role of specific HLA types in the genetic predisposition to this rare autoimmune eye disease.