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Related Experiment Videos

Exploratory data analysis groupware for qualitative and quantitative electrophoretic gel analysis over the

P F Lemkin1, J M Myrick, Y Lakshmanan

  • 1Laboratory Experimental & Computational Biology, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702, USA. lemkin@ncifcrf.gov

Electrophoresis
|December 28, 1999
PubMed
Summary

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WebGel is a web-based system for sharing and analyzing electrophoretic gel data online. It enhances collaborative research by enabling interactive exploration of quantitative and qualitative differences between gels.

Area of Science:

  • Biotechnology
  • Bioinformatics
  • Computational Biology

Background:

  • Scientists analyze protein and nucleotide data from electrophoretic gels using quantitative measurements.
  • Digital image files of gels are common, with quantification performed by stand-alone software.
  • The need for sharing intermediate quantitative data among collaborators over the internet has increased.

Purpose of the Study:

  • To develop a World Wide Web group-accessible software system, WebGel, for interactive exploration of electrophoretic gel data.
  • To facilitate the sharing of intermediate quantitative and qualitative data among research collaborators.
  • To enhance collaborative research through a groupware method for active data-sharing.

Main Methods:

  • Quantitative and image gel data are copied to a database on the WebGel Web server.

Related Experiment Videos

  • WebGel provides interactive analysis tools, including visualization of gel images and spot montages.
  • Qualitative analysis uses Flicker-comparison, and quantitative analysis compares protein concentration values across gels.

    • Main Results:

    • WebGel enables interactive exploration of qualitative and quantitative differences between electrophoretic gels.
    • The system organizes labeled gel images into montages for easy comparison.
    • Data analysis includes generating reports on statistical differences between sets of gels, aiding in disease state comparisons.

    Conclusions:

    • WebGel serves as a collaborative Internet tool, bridging the analysis of dissimilar gels.
    • It enhances collaborative research by providing a groupware method for active data-sharing.
    • The system facilitates the publishing and exploration of quantitative gel data for broader research impact.