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Related Experiment Videos

TGF-beta3 exists in bony fish.

K J Laing1, L Pilström, C Cunningham

  • 1Department of Zoology, University of Aberdeen, Aberdeen, UK.

Veterinary Immunology and Immunopathology
|December 30, 1999
PubMed
Summary

Transforming growth factor-beta3 (TGF-beta3) is widespread in bony fish and highly conserved, showing significant similarity to mammalian TGF-beta3. This finding supports the evolutionary conservation of TGF-beta3 across vertebrates.

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Area of Science:

  • Evolutionary Biology
  • Molecular Biology
  • Fish Biology

Background:

  • Transforming growth factor-beta (TGF-beta) signaling pathways are crucial for cellular processes.
  • TGF-beta3 is a key isoform involved in development and tissue repair.
  • Understanding TGF-beta3 conservation across diverse species provides insights into its fundamental roles.

Purpose of the Study:

  • To investigate the presence and conservation of transforming growth factor-beta3 (TGF-beta3) in ray-finned bony fish.
  • To compare the nucleotide and amino acid identities of fish TGF-beta3 with those of homeotherms and other fish TGF-beta isoforms.
  • To analyze the phylogenetic relationships of fish TGF-beta3.

Main Methods:

  • Isolation of partial nucleotide sequences of TGF-beta3 from Siberian sturgeon, rainbow trout, and European eel.

Related Experiment Videos

  • Sequence alignment and identity analysis (nucleotide and amino acid).
  • Phylogenetic tree construction to assess evolutionary relationships.

    • Main Results:

    • TGF-beta3 was identified in Siberian sturgeon, rainbow trout, and European eel, indicating its ubiquitous presence in Actinopterygian fish.
    • Fish TGF-beta3 exhibited high nucleotide (83-84%) and amino acid (90-95%) identity to homeotherm TGF-beta3.
    • Lower homologies were observed with fish TGF-beta1, TGF-beta2, and TGF-beta5, with phylogenetic analysis clustering fish TGF-beta3 with homeotherm TGF-beta3.

    Conclusions:

    • TGF-beta3 is a highly conserved gene across bony fish and homeotherms.
    • The findings support the evolutionary conservation of TGF-beta3's structure and function.
    • TGF-beta5 represents a more divergent group within fish TGF-beta isoforms.