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Related Experiment Videos

Extrathymic CD4/CD8 double positive T cells.

F A Zuckermann1

  • 1Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61801, USA. fazaaa@uiuc.edu

Veterinary Immunology and Immunopathology
|December 30, 1999
PubMed
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Unconventional CD4/CD8 double-positive (DP) T cells, rare in humans but common in swine and monkeys, challenge traditional lymphocyte classification. These cells may represent a primed T cell subset with significant immunological roles.

Area of Science:

  • Immunology
  • Cell Biology
  • T lymphocyte research

Background:

  • Mature T cells are typically classified as CD4+ or CD8+.
  • CD4/CD8 double-positive (DP) T cells are unconventional lymphocytes that challenge this binary classification.
  • DP T cells are found in various species, including swine, chickens, monkeys, humans, and rats, with varying prevalence.

Purpose of the Study:

  • To review the evidence for extrathymic CD4/CD8 DP lymphocytes across species.
  • To investigate the characteristics and potential functional significance of DP T cells.
  • To challenge the traditional view of mutually exclusive CD4 and CD8 expression on T cells.

Main Methods:

  • Review of existing literature and reports on CD4/CD8 DP lymphocytes.
  • Phenotypic analysis of lymphocytes in swine, monkeys, and other species.

Related Experiment Videos

  • Comparison of DP T cell characteristics across different species.

    • Main Results:

    • Significant numbers of CD4/CD8 DP lymphocytes exist in swine, chickens, and monkeys.
    • DP T cells can be found in human peripheral blood, especially during disease or inflammation.
    • Porcine DP T cells are predominantly MHC class II restricted memory CD4+ helper T cells that acquire CD8alpha expression post-activation.

    Conclusions:

    • CD4/CD8 DP T cells represent a distinct, primed T cell subset in swine, humans, and monkeys.
    • These cells exhibit memory characteristics, including antigen recall response and interferon-gamma production.
    • The simultaneous expression of CD4 and CD8 co-receptors on mature T cells warrants further functional investigation.