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Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C
M J Comin1, C A Pujol, E B Damonte
1Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Nucleosides & Nucleotides
|January 5, 2000
Abstract:
Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.