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[Fatal mesenteric ischemic accident caused by mesenteric inflammatory veno-occlusive disease]

D Satgé1, P Jardel, E Lavoine

  • 1Laboratoire d'Anatomie Pathologique, Centre Hospitalier, Tulle.

Annales De Pathologie
|January 5, 2000
PubMed

Insights

Mesenteric inflammatory veno-occlusive disease caused rapid death from intestinal ischemia in a patient. This rare vasculitis affects only mesenteric veins, leading to lumen reduction and potential organ damage.

Area of Science:

  • Gastroenterology
  • Vascular Medicine
  • Pathology

Background:

  • Mesenteric inflammatory veno-occlusive disease (MIVOD) is a rare vasculitis affecting mesenteric veins.
  • First described in 1994, its etiology remains unknown.
  • It exclusively impacts veins and venules, sparing arteries.

Observation:

  • A 72-year-old woman experienced massive intestinal and colonic ischemia.
  • This led to rapid post-operative death.
  • Her case exhibited numerous polymorphonuclear eosinophils.

Findings:

  • Histological examination revealed acute phlebitis (lymphocytic, necrotizing, granulomatous) and chronic myointimal hyperplasia.
  • The venous lumen reduction was a key pathological feature.
  • Eosinophilic infiltration was a prominent finding in this specific case.

Implications:

  • MIVOD can lead to severe mesenteric ischemia and high mortality.
  • Early recognition and understanding of MIVOD pathogenesis are crucial.
  • Further research into MIVOD etiology and effective treatments is warranted.

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