Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prefrontal cortex and episodic memory retrieval mode.

M Lepage1, O Ghaffar, L Nyberg

  • 1Rotman Research Institute of Baycrest Centre, 3560 Bathurst Street, Toronto, ON, M6A 2E1, Canada. mlepage@rotman-baycrest.on.ca

Proceedings of the National Academy of Sciences of the United States of America
|January 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining a recovery definition and core outcomes of psychosis: protocol of an international Delphi consensus study.

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2026
Same author

Pre-onset subthreshold psychotic symptoms are associated with differential treatment delays before a first episode of psychosis: Initial evidence and implications.

Schizophrenia research·2024
Same author

Social and occupational recovery in early psychosis: a systematic review and meta-analysis of psychosocial interventions.

Psychological medicine·2021
Same author

Pre-onset sub-threshold psychotic symptoms and cortical organization in the first episode of psychosis.

Progress in neuro-psychopharmacology & biological psychiatry·2020
Same author

Medication adherence in first episode psychosis: the role of pre-onset subthreshold symptoms.

Acta psychiatrica Scandinavica·2019
Same author

Anxiety in youth at clinical high risk for psychosis: A case study and conceptual model.

Schizophrenia research·2019
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Neuroimaging reveals specific prefrontal cortex sites crucial for episodic memory retrieval mode (REMO), the state necessary for recalling past experiences. These findings clarify the brain regions involved in remembering and may explain frontal asymmetry in memory retrieval.

Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Neurobiology

Background:

  • Episodic memory retrieval relies on a specific cognitive state known as retrieval mode (REMO).
  • Previous functional neuroimaging studies have observed frontal lobe activations during episodic memory retrieval, but their precise role has remained unclear.
  • Understanding the neural correlates of REMO is essential for comprehending the mechanisms of remembering past experiences.

Purpose of the Study:

  • To identify specific brain regions associated with the maintenance of episodic memory retrieval mode (REMO).
  • To investigate the role of prefrontal cortical sites in REMO.
  • To examine whether REMO activations explain the frontal hemispheric asymmetry observed in memory retrieval.

Main Methods:

  • Multistudy analysis of positron emission tomography (PET) data.

Related Experiment Videos

  • Identification of cortical sites where neuronal activity correlates with REMO.
  • Localization of identified sites using Brodmann's areas (BA).

    • Main Results:

    • Three right prefrontal cortical sites (near BA 10, BA 47/45, BA 8/9) and two left prefrontal sites (homotopical to right sites) were identified.
    • A region in the anterior cingulate gyrus also showed activity correlated with REMO.
    • These REMO-associated sites were specific to the prefrontal cortex and anterior cingulate gyrus.

    Conclusions:

    • The identified prefrontal and anterior cingulate sites are critical for maintaining episodic memory retrieval mode (REMO).
    • These REMO activations likely account for the previously described frontal hemispheric asymmetry in episodic memory retrieval.
    • The findings provide a clearer understanding of the neural basis of remembering and frontal lobe function in memory.