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Disodium cromoglycate use in children and adolescents with asthma: correlation between plasma concentrations and
1Department of Pediatrics Hiroshima University School of Medicine, Minami-Ku, Japan. ykatoh@mcai.med.hiroshima-u.ac.jp
Background:
Few studies have addressed the association between the plasma concentration of disodium cromoglycate and its protective effects on patients with bronchial asthma.
Objective:
We measured plasma concentrations of disodium cromoglycate for various asthmatic treatments in children and adolescents and estimated plasma concentrations and protective effects.
Method:
Disodium cromoglycate as a 2-mg aerosol (n = 12), 4-mg aerosol (n = 5), or 20-mg nebulizer solution (n = 13) was inhaled by patients in remission.
Results:
The plasma concentrations of disodium cromoglycate after 5 minutes of inhalation were 3.04 +/- 2.72 ng/mL in the 2-mg aerosol group, 2.95 +/- 0.86 ng/mL in the 4-mg aerosol group, and 7.72 +/- 4.65 ng/mL in the nebulizer solution group. Subjects who used the nebulizer exhibited markedly higher plasma concentrations of disodium cromoglycate. There was a significant correlation between the concentration of disodium cromoglycate at 5 minutes and the protective effect determined by a ratio of the difference in the asthma score between baseline and treatment periods to the baseline asthma score.
Conclusion:
When the plasma concentration of disodium cromoglycate is low, administration of larger aerosol dose or nebulization might be necessary.