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Lung delivery of aerosolized dextran
W H Finlay1, C F Lange, M King
1Aerosol Research Laboratory, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada. warren.finlay@ualberta.ca
American Journal of Respiratory and Critical Care Medicine
|January 5, 2000
Abstract:
The ability of nebulizers to deliver dextran (nominal molecular mass, 4,000 g/mol) to the lung as an inhaled aerosol is evaluated by in vitro experimental methods and mathematical models. Dextran in isotonic saline was aerosolized by four nebulizer types (Pari LC STAR, Hudson T-Updraft II, Acorn II, and Sonix 2000) at dextran concentrations