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[Liver involvement in coeliac disease]
S Riestra1, E Fernández, L Rodrigo
1Sección de Aparato Digestivo, Hospital "Valle del Nalón", Riaño-Langreo, Asturias, 33920, España.
Revista Espanola De Enfermedades Digestivas
|January 5, 2000
Summary
Coeliac disease, an autoimmune disorder triggered by gluten, can affect the liver. This review explores liver damage in coeliac patients, including asymptomatic liver enzyme elevations and associations with autoimmune liver diseases.
Area of Science:
- Gastroenterology and Hepatology
- Immunology
Context:
- Coeliac disease is a complex autoimmune disorder.
- Extraintestinal manifestations are common in coeliac disease.
- Liver involvement is increasingly recognized in coeliac disease.
Purpose:
- To review hepatic diseases associated with coeliac disease.
- To discuss diagnostic and therapeutic approaches for liver conditions in coeliac patients.
- To highlight the link between coeliac disease and autoimmune liver diseases.
Summary:
- Coeliac disease frequently presents with asymptomatic hypertransaminasemia, often resolving with gluten withdrawal and typically showing non-specific reactive hepatitis.
- Coeliac disease is a known cause of unexplained elevated liver enzymes (cryptogenic hypertransaminasemia).
- A subset of coeliac patients exhibit associations with autoimmune liver diseases, notably autoimmune hepatitis and primary biliary cirrhosis, though evidence for rarer hepatic conditions is less robust.
Impact:
- Emphasizes the liver as an extraintestinal site affected by coeliac disease.
- Provides a framework for diagnosing and managing liver abnormalities in coeliac patients.
- Underscores the importance of considering coeliac disease in patients with unexplained liver enzyme elevations and autoimmune liver conditions.