Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mania associated with St. John's wort.

A A Nierenberg1, T Burt, J Matthews

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Biological Psychiatry
|January 7, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The GEMstone Maze: Gamification of Medical Skills and Knowledge.

The clinical teacher·2026
Same author

Energy Spectrum of Ultrahigh-Energy Cosmic Rays across Declinations -90° to +44.8° as Measured at the Pierre Auger Observatory.

Physical review letters·2026
Same author

Search for Light Dark Matter with NEWS-G at the Laboratoire Souterrain de Modane Using a Methane Target.

Physical review letters·2025
Same author

Search for the Anomalous Events Detected by ANITA Using the Pierre Auger Observatory.

Physical review letters·2025
Same author

Inference of the Mass Composition of Cosmic Rays with Energies from 10^{18.5} to 10^{20}  eV Using the Pierre Auger Observatory and Deep Learning.

Physical review letters·2025
Same author

Demonstrating Agreement between Radio and Fluorescence Measurements of the Depth of Maximum of Extensive Air Showers at the Pierre Auger Observatory.

Physical review letters·2024
Same journal

Functional connectivity of orbitofrontal cortex predicts cocaine relapse: Protective and risk circuits, individual differences, and neuromodulation implications.

Biological psychiatry·2026
Same journal

Takeda G protein-coupled receptor 5 orchestrates anxiolysis by enhancing anterior paraventricular thalamic nucleus glutamatergic neuronal activity to engage distinct downstream circuits.

Biological psychiatry·2026
Same journal

Neuroimaging of Heterogeneity in Neuropsychiatric Disorders: Toward Disease Progression Modeling.

Biological psychiatry·2026
Same journal

Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

Biological psychiatry·2026
Same journal

Remembering Jon-Kar Zubieta, M.D., Ph.D.

Biological psychiatry·2026
Same journal

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026
See all related articles

St. John's wort, an herbal antidepressant, may trigger mania or mood cycling in individuals with undiagnosed bipolar disorder. Healthcare providers should screen patients for bipolar history before recommending this popular supplement.

Area of Science:

  • Herbal medicine
  • Psychiatry
  • Pharmacology

Background:

  • St. John's wort is a widely used herbal remedy for depression.
  • It is generally perceived as having a benign side effect profile.
  • Its antidepressant efficacy warrants investigation into potential mood-altering effects.

Observation:

  • This report details two cases where mania was linked to St. John's wort (Hypericum) use.
  • The observed mania occurred temporally in association with the herbal supplement's consumption.

Findings:

  • St. John's wort, similar to other antidepressants, can induce hypomania, mania, or mood state acceleration.
  • This risk is heightened in individuals with underlying, undiagnosed bipolar disorder.

Implications:

Related Experiment Videos

  • The widespread use of St. John's wort without psychiatric evaluation poses a significant risk for inducing mania.
  • Clinicians must assess patients for prior episodes of hypomania or mania before prescribing St. John's wort.
  • This highlights the importance of careful patient selection and monitoring when using herbal remedies with potential psychoactive effects.