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Septic shock from the administration of a bacterially contaminated platelet transfusion
P E Neff1, K P Kelly, J D Tobias
1Department of Child Health, University of Missouri, Columbia 65212, USA.
Abstract:
We report the case of a 6-year-old boy who began to have fever and hypotension during the administration of a platelet transfusion. Subsequent investigation revealed the etiology to be bacterial contamination of the platelet product. Seratia marcescens was cultured from both the patient's blood and the platelet product. When fever and/or cardiorespiratory problems develop during the administration of blood products, possible bacterial contamination of the product must be considered so that appropriate therapy can be instituted. We discuss the etiology, possible preventive strategies, and the treatment of this problem.
Insights
Bacterial contamination of platelet transfusions can cause fever and hypotension. Prompt recognition and treatment are crucial for patient safety during blood product administration.
Area of Science:
- Hematology
- Infectious Diseases
- Patient Safety
Background:
- Platelet transfusions are vital for managing various hematological conditions.
- Ensuring the safety of blood products is paramount in clinical practice.
Observation:
- A 6-year-old boy developed fever and hypotension during a platelet transfusion.
- The patient's symptoms were linked to bacterial contamination of the transfused product.
Findings:
- Seratia marcescens was identified as the causative agent, cultured from both the patient's blood and the platelet unit.
- This case highlights bacterial contamination as a potential risk during platelet transfusion.
Implications:
- Clinicians must consider bacterial contamination in patients experiencing adverse reactions during blood product administration.
- Implementing preventive strategies and prompt therapeutic interventions are essential to mitigate risks associated with contaminated blood products.