Experimental osteogenesis at fracture sites and gaps

One hundred and twenty male albino rats were used to study the regenerative potential of periosteum, and the effects of the size of discontinuity defects on bone repair. The clinical, radiologic, and histological studies disclosed new bone formation and remodeling of fibular fractures and gaps in the presence of periosteum or bone contact, or both. Small and large fibular fracture gaps without periosteum resulted in nonunion, interposition of fibrous tissue, and no new bone formation. It was concluded from the current experimental studies that bone contact is more important than periosteum for normal bone healing. Where contact is not possible, the presence of periosteum assumes a more essential role.