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Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Mutation reports: epidermolysis bullosa simplex associated with severe mucous membrane involvement and novel mutations in the plectin gene.

The Journal of investigative dermatology·2000
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Epidermolysis bullosa: novel and de novo premature termination codon and deletion mutations in the plectin gene predict late-onset muscular dystrophy.

The Journal of investigative dermatology·2000
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Molecular genetics of Meesmann's corneal dystrophy: ancestral and novel mutations in keratin 12 (K12) and complete sequence of the human KRT12 gene.

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Compound heterozygosity for novel splice site mutations in the BPAG2/COL17A1 gene underlies generalized atrophic benign epidermolysis bullosa.

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Combination of novel premature termination codon and glycine substitution mutations in COL7A1 leads to moderately severe recessive dystrophic epidermolysis bullosa.

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Related Experiment Video

Updated: Jul 18, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
06:37

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery

Published on: October 18, 2012

Cutaneous gene therapy. Principles and prospects.

M T Lin1, L Pulkkinen, J Uitto

  • 1Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.

Dermatologic Clinics
|January 8, 2000
PubMed
Summary

Gene therapy is increasingly important for dermatologists, with new applications in cancer therapy and vaccination beyond gene replacement. Various gene delivery systems are under investigation for treating skin diseases.

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Last Updated: Jul 18, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
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Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
09:42

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

Published on: April 19, 2017

Area of Science:

  • Dermatology
  • Molecular Biology
  • Gene Therapy

Background:

  • Gene therapy is gaining traction in dermatology, bridging basic research and clinical applications.
  • Advances in gene-based cancer therapy, DNA vaccination, and molecular pharmacology are expanding its scope.
  • Traditional gene replacement is no longer the sole focus of gene therapy research.

Purpose of the Study:

  • To summarize the principles of gene therapy.
  • To review current and potential applications of gene therapy in cutaneous diseases.
  • To discuss the advantages and disadvantages of different gene delivery systems.

Main Methods:

  • Review of current literature on gene therapy principles and applications.
  • Analysis of various gene delivery systems.
  • Focus on advancements relevant to dermatological conditions.

Main Results:

  • Gene therapy offers novel approaches for skin conditions, including cancer and infectious diseases.
  • Diverse gene delivery systems exist, each with unique benefits and drawbacks.
  • The field is rapidly evolving beyond traditional gene replacement.

Conclusions:

  • Gene therapy holds significant promise for treating a range of cutaneous diseases.
  • Understanding gene therapy principles and delivery systems is crucial for dermatologists.
  • Continued research is essential to optimize gene therapy for skin applications.