Related Experiment Videos
Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the
M Sharif1, L Shepstone, C J Elson
1Rheumatology Unit, University Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW.
Insights
Serum CRP measured three years prior to assessment, and serum HA at assessment, predict knee osteoarthritis progression. However, neither biomarker reliably predicts individual patient outcomes due to poor specificity and sensitivity.
Area of Science:
- Biomarkers in Osteoarthritis Research
- Radiographic Progression Analysis
- Longitudinal Study Design
Background:
- Elevated serum C-reactive protein (CRP) and hyaluronate (HA) are linked to long-term knee osteoarthritis (OA) progression.
- The temporal consistency of these biomarker-progression relationships over time remains unclear.
Purpose of the Study:
- To investigate if serum CRP and HA concentrations at baseline and three years prior predict knee OA radiological progression over five years.
Main Methods:
- Knee OA progression was assessed using radiographs from 90 patients over five years.
- Serum CRP and HA levels were measured at baseline and, for CRP and HA, at three years prior.
- Logistic regression analysis calculated odds ratios for progression prediction.
Main Results:
- Serum CRP at three years prior predicted progression (OR 1.90), but not at baseline (OR 1.12).
- Serum HA at baseline predicted progression (OR 2.32).
- Significant overlap between groups limited predictive accuracy for individual patients.
Conclusions:
- Raised serum CRP may indicate events preceding later knee OA radiographic progression.
- Serum HA concentration at baseline is a predictor of subsequent OA progression.
- Neither serum CRP nor HA are reliable predictors for individual knee OA progression due to low sensitivity and specificity.
Objective:
Raised serum C reactive protein (CRP) and hyaluronate (HA) concentrations predict the progression of knee osteoarthritis (OA) in the long term but the consistency of these relations with time is unknown. The purpose of this work was therefore to determine if raised CRP and HA at entry and three years before entry (-3 years) predict radiological progression of knee OA in a group of patients between entry and five years.
Methods:
Knee radiographs from 90 patients with knee OA at entry and five years follow up were assessed for progression of disease over five years. The concentrations of serum CRP and HA were measured at entry (n=90) and also in 40 serum samples available from -3 years. Odds ratios (OR) for predicting progression were calculated by logistic regression.
Results:
Serum CRP at entry was not predictive of progression between entry and five years (OR 1.12, 95% CI 0.81, 1.55) but serum CRP at -3 years was predictive of progression (OR 1.90, 95% CI 1.01, 3.28). Serum HA concentration at entry predicted progression between entry and five years (OR 2.32, 95% CI 1.16, 4.66).
Conclusion:
These results are consistent with previous reports relating to HA, and suggest that raised serum CRP reflects events that precede a period of later radiographic progression in knee OA. However, because of the large overlap between groups, the serum CRP or HA concentration are not good predictors of individual patient progression and have a poor sensitivity and specificity.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:23Rheumatic Heart Disease I: Introduction
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT