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Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system
T Reuter1, S Herterich, O Bernhard
1Departments of Biochemistry and Human Genetics, University of Würzburg, Würzburg, Germany. reuter@biozentrum.uni-wuerzburg
Blood
|January 11, 2000
Abstract:
Three of at least 8 Fanconi anemia (FA) genes have been cloned (FANCA, FANCC, FANCG), but their functions remain unknown. Using the yeast 2-hybrid system and full-length cDNA, the authors found a strong interaction between FANCA and FANCG proteins. They also obtained evidence for a weak interaction between FANCA and FANCC. Neither FANCA nor FANCC was found to interact with itself. These results support the notion of a functional association between the FA gene products. (Blood. 2000;95:719-720)