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Updated: Jun 25, 2026

Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Molecular pathology of allergic disease: I: lower airway disease
1Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Abstract:
Asthma is a complex disorder associated with eosinophil infiltration and the activation of T lymphocytes within the airways. Recent advances in the pathophysiologic mechanisms of asthma point to the importance of eosinophil-basophil progenitor cells and a family of transcription factors that underlie the development of T(H)2-type responses. Further research is needed to address the development of chronic inflammatory changes, the role of profibrotic cytokines, and especially their reliance on eosinophils in the lungs.
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