Experimental studies with Stronglyloides papillosus in goats

Area of Science:

• Veterinary Parasitology
• Animal Pathology

Background:

• Strongyloides papillosus infections in goats and sheep present unusual clinical and pathological findings.
• Field observations prompted experimental investigations into the parasite's effects.

Purpose of the Study:

• To experimentally infect goats with Strongyloides papillosus to characterize clinical signs, pathological changes, and immunity.
• To determine the susceptibility of different age groups of goats.

Main Methods:

• Goats of various ages were infected percutaneously with different doses of S. papillosus larvae.
• Clinical signs, pathological lesions, and acquired immunity were monitored.
• Clinicopathological parameters, including trace element levels, were analyzed.

Main Results:

• Young goats (up to 12 months) were most susceptible, exhibiting diarrhea, anemia, neurological signs, and cachexia.
• Pathological changes included enteritis, brain lesions (status spongiosus), liver rupture, nephrosis, and pneumonia.
• Acquired immunity was observed, indicated by skin reactions, but could be overcome by high larval doses.
• Anemia and hypophosphatemia were the most significant clinicopathological findings, with evidence of trace element deficiencies (Cu, Mn, Se).

Conclusions:

• Strongyloides papillosus infection poses a significant threat to young goats, causing severe clinical and pathological manifestations.
• Acquired immunity offers some protection but is not absolute against high parasite burdens.
• The study highlights the importance of considering trace element status in managing S. papillosus infections.