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Chasing behaviour genes into the next millennium.

I W Craig1, J McClay, R Plomin

  • 1Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK. i.craig@iop.kcl.ac.uk

Trends in Biotechnology
|January 13, 2000
PubMed
Summary
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Linkage and association strategies effectively characterize genes linked to human behavior and disorders. Future whole-genome studies will integrate single-nucleotide and simple-sequence-repeat polymorphisms for comprehensive genetic analysis.

Area of Science:

  • Genetics
  • Behavioral Science
  • Human Genomics

Background:

  • Human behavioral dimensions and disorders have complex genetic underpinnings.
  • Characterizing these genetic factors is crucial for understanding and treating related conditions.

Purpose of the Study:

  • To evaluate the suitability of linkage and association strategies for identifying genes related to human behavior.
  • To outline future directions for genetic studies in behavioral research.

Main Methods:

  • Review and synthesis of existing genetic research methodologies.
  • Discussion of the application of linkage analysis and association studies.
  • Consideration of whole-genome scanning approaches.

Main Results:

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  • Both linkage and association strategies are deemed appropriate for characterizing genes in human behavioral dimensions and disorders.
  • Future research will likely combine these strategies.

Conclusions:

  • Genetic research into human behavior benefits from both linkage and association studies.
  • Integration of single-nucleotide polymorphisms and simple-sequence-repeat polymorphisms in whole-genome association studies is recommended for future research.