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Updated: Jul 28, 2026

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
Herbal preparations: a primer for the aeromedical physician
1United States Air Force School of Aerospace Medicine, Brooks Air Force Base, TX 78235, USA. charles.fisher@mirage.brooks.af.mil
Aviators are increasingly using botanical products, posing risks to aviation safety. Flight surgeons must identify use and assess potential dangers for pilots.
Area of Science:
- Aviation toxicology
- Herbal medicine safety
- Aeromedical safety
Background:
- Herbal preparations are widely used, with potential risks yet unknown among aviators.
- Current regulations do not require disclosure or inquiry into aviator use of botanical supplements.
- Assessing the safety of botanical products for aviators is crucial for aviation safety.
Purpose of the Study:
- Identify botanical preparations posing risks to aviator and aviation safety.
- Determine the prevalence of dietary supplement use among aviators.
- Develop a method for assessing the suitability of botanical products for aviator use.
Main Methods:
- Analyzed toxicological data from 3177 mishap pilots (1989-1997).
- Screened for ephedrine as an indicator of botanical substance use.
- Reviewed literature on botanical agents' risks to aviator health and aviation safety.
Main Results:
- Ephedrine was the only routinely screened substance linked to botanical use.
- Positive ephedrine results increased significantly, while similar non-botanical substances decreased.
- Many legal botanical agents can cause incapacitation via cardiovascular or neuropsychiatric effects.
Conclusions:
- Aviator use of risky botanical products is increasing.
- These products pose significant risks of incapacitation and adverse health effects.
- Flight surgeons need to actively identify use and manage risks to flight safety.
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