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The evolution of pathogenic trypanosomes.

J R Stevens1, W C Gibson

  • 1School of Biological Sciences, University of Exeter, Exeter EX4 4PS, UK. j.r.stevens@exeter.ac.uk

Cadernos De Saude Publica
|January 14, 2000
PubMed
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Molecular data reveal that trypanosomes are monophyletic, offering a framework to understand their evolution, host coevolution, and the history of diseases like those caused by Trypanosoma brucei and Trypanosoma cruzi.

Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Parasitology

Background:

  • Protozoa evolution was speculative without a fossil record.
  • Molecular methods and phylogenetic analysis now enable gene-based evolutionary studies.

Purpose of the Study:

  • Reconstruct trypanosome phylogeny using molecular data.
  • Establish a framework for reinterpreting trypanosome biology, taxonomy, and distribution.
  • Investigate the coevolution of trypanosomes with hosts and vectors.

Main Methods:

  • Analysis of molecular data from ribosomal RNA.
  • Phylogenetic analysis using miniexon and protein-coding genes.
  • Review of different lineage divergence dating methods.

Main Results:

Related Experiment Videos

  • Unequivocal evidence demonstrates that trypanosomes are monophyletic.
  • Phylogenetic trees provide a basis for reinterpreting trypanosome biology and taxonomy.
  • Biogeographically informed dating offers insights into host-pathogen coevolution.

Conclusions:

  • Molecular data have resolved trypanosome phylogeny.
  • Phylogenetic framework aids understanding of trypanosome evolution and coevolution with hosts.
  • Specific pathogens like Trypanosoma brucei and Trypanosoma cruzi coevolved with human hosts.