Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anorectal function in multiple system atrophy and Parkinson's disease.

F Stocchi1, D Badiali, L Vacca

  • 1Department of Neuroscience, University La Sapienza Rome, Italy.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 14, 2000
PubMed
Summary

Bowel and anorectal dysfunction are common in Parkinson's disease (PD) and multiple system atrophy (MSA). While manometric patterns do not differentiate these conditions, abnormalities appear earlier in MSA patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study.

NPJ Parkinson's disease·2024
Same author

Altered sensorimotor integration in multiple sclerosis: A combined neurophysiological and functional MRI study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Abnormal motor surround inhibition associated with cortical and deep grey matter involvement in multiple sclerosis.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Is there evidence of bradykinesia in essential tremor?

European journal of neurology·2020
Same author

Does EMG provide essential information for the diagnosis and treatment of blepharospasm?

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2020
Same author

Corticobasal syndrome: neuroimaging and neurophysiological advances.

European journal of neurology·2019

Area of Science:

  • Neurology
  • Gastroenterology
  • Physiology

Background:

  • Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative disorders.
  • Both conditions can present with significant gastrointestinal and anorectal dysfunction.
  • Understanding the nuances of anorectal function is crucial for patient management.

Purpose of the Study:

  • To investigate and compare anorectal function in patients with PD and MSA.
  • To determine if specific manometric patterns can differentiate between PD and MSA.
  • To assess the prevalence and characteristics of bowel and anorectal dysfunction in these patient groups.

Main Methods:

  • Standardized patient interviews were conducted.
  • Anorectal manometry was performed using a multi-lumen catheter and rectal distension balloon.

Related Experiment Videos

  • Data analysis was performed by observers blinded to the neurological diagnosis.

    • Main Results:

    • Disease duration was shorter in the MSA group (6+/-4 yrs) compared to the PD group (10+/-5 yrs).
    • Most patients in both groups reported infrequent bowel movements and some experienced fecal incontinence.
    • Abnormal straining patterns were observed in most patients with MSA (13/16) and PD (11/17), but manometric patterns did not differentiate the two groups.

    Conclusions:

    • Bowel and anorectal dysfunctions are prevalent in both PD and MSA.
    • Manometric findings do not reliably distinguish between PD and MSA.
    • Anorectal dysfunction appears to develop earlier and progress faster in MSA than in PD.