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Normal immune responses to ingested foods.

S Husby1

  • 1Department of Pediatrics, Odense University Hospital, Denmark.

Journal of Pediatric Gastroenterology and Nutrition
|January 14, 2000
PubMed
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Dietary antigens trigger normal immune responses, including antibodies and T-cells, in the body. This review highlights that oral tolerance, particularly in the T-cell system, is a key regulatory mechanism in humans.

Area of Science:

  • Immunology
  • Gastroenterology
  • Food Science

Background:

  • Dietary antigens are absorbed into circulation.
  • B-cell and T-cell responses to food antigens occur in healthy individuals.
  • Low levels of Immunoglobulin E (IgE) and specific T-cell responses are normal phenomena.

Purpose of the Study:

  • To review the literature on immune responses to dietary antigens.
  • To discuss the phenomenon of oral tolerance in humans.
  • To explore the role of oral tolerance in regulating immunity.

Main Methods:

  • Literature review with author's work bias.
  • Analysis of B-cell and T-cell responses to food antigens.
  • Examination of antibody production and cytokine profiles.

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Main Results:

  • Food antigens elicit physiological B-cell responses (antibodies) in circulation.
  • IgA anti-gliadin antibodies are an exception to general antibody patterns.
  • T-cell responses to food are typically low in circulation but higher in the gastrointestinal mucosa.

Conclusions:

  • Oral tolerance is a genuine phenomenon in humans.
  • Oral tolerance, especially within the T-cell system, is crucial for normal immune regulation.
  • Understanding these responses is key to managing food-related immune conditions.