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Related Experiment Videos

Morphometric and ultrastructural changes with ageing in mouse peripheral nerve.

D Ceballos1, J Cuadras, E Verdú

  • 1Department of Cell Biology and Physiology, Universitat Autònoma de Barcelona, Bellaterra, Spain.

Journal of Anatomy
|January 14, 2000
PubMed
Summary
This summary is machine-generated.

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Peripheral nerve aging in mice shows collagen buildup and cell changes. Older nerves experience significant fiber loss, particularly unmyelinated axons, leading to disorganization.

Area of Science:

  • Neuroscience
  • Gerontology
  • Histology

Background:

  • Peripheral nerve aging involves complex cellular and structural modifications.
  • Understanding these changes is crucial for addressing age-related neurological deficits.

Purpose of the Study:

  • To quantitatively and qualitatively analyze morphological changes in mouse peripheral nerves throughout their lifespan.
  • To identify key age-related alterations in nerve fibers and non-neuronal cells.

Main Methods:

  • Histological examination of tibial nerves from mice aged 6 to 33 months.
  • Morphometric analysis of nerve fibers, Schwann cells, and associated cellular components.

Main Results:

  • Age-related accumulation of collagen in the perineurium and lipid droplets in perineurial cells.

Related Experiment Videos

  • Increased macrophage and mast cell populations, with frequent onion bulbs and collagen pockets.
  • A decrease in the unmyelinated axon to myelinated fiber ratio and significant loss of unmyelinated axons in older mice.
  • Demyelination, remyelination, widened incisures, and myelin loop irregularities observed in aged nerves.

    • Conclusions:

    • Mouse peripheral nerves exhibit progressive degeneration from 12-20 months, culminating in disorganization and marked fiber loss after 20 months.
    • Unmyelinated axons are more vulnerable to age-related loss than myelinated fibers.
    • These findings provide a detailed timeline of peripheral nerve aging in mice.