Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

Area of Science:

• Biomedical Engineering
• Neuroscience
• Regenerative Medicine

Background:

• Artificial prostheses are crucial for hand amputation recovery.
• Current regenerative nerve electrodes often hinder nerve regrowth.
• High selectivity is needed for effective neural interfacing.

Purpose of the Study:

• To develop a non-obstructive regenerative electrode for improved nerve repair.
• To enable selective neural recording and stimulation with regrowing nerves.
• To facilitate functional recovery in neuroprosthetic applications.

Main Methods:

• Designed a double-aisle electrode using thin-film polyimide.
• Enabled two nerve fascicles to regenerate through isolated aisles.
• Utilized a multi-contact planar electrode design.

Main Results:

• Demonstrated high transparency and non-obstructive nerve regeneration.
• Achieved selective fascicle recording and stimulation, acutely and chronically.
• Supported nerve regeneration across several millimeters without impairment.

Conclusions:

• The double-aisle electrode promotes unimpeded nerve regeneration.
• This technology offers potential for advanced neuroprosthetic hand function restoration.
• The electrode design is suitable for treating severe nerve injuries.