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Updated: Aug 3, 2026

Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy
Published on: November 30, 2018
Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor
13-Dimensional Pharmaceutical, Inc., Eagleview Corporate Center, Exton, PA 19341, USA.
Abstract:
The structure activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.
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