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Percutaneous penetration enhancers: local versus transdermal activity
1Dept of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Pharmaceutical Science & Technology Today
|January 19, 2000
Summary
Researchers are exploring skin permeation enhancers and retardants for drug delivery. This research aims to find safer compounds for topical formulations, balancing efficacy with reduced side effects for better skin treatments.
Area of Science:
- Dermatology
- Pharmaceutics
- Materials Science
Background:
- The stratum corneum presents a significant barrier for topical drug delivery.
- Traditional permeation enhancers often cause adverse side effects.
- There is a growing need for safer and effective skin penetration modifiers.
Purpose of the Study:
- To investigate compounds that can enhance or retard skin permeation.
- To identify agents with low toxicity for topical formulations.
- To understand structure-activity relationships for both enhancers and retardants.
Main Methods:
- Review of existing literature on skin permeation.
- Analysis of chemical compounds used as permeation modifiers.
- Exploration of structure-activity relationships.
Main Results:
- Development of traditional permeation enhancers often led to toxicity.
- Emerging research focuses on low-toxicity compounds for enhanced permeation.
- Interest is growing in skin retardants for localized topical applications.
Conclusions:
- Research into skin permeation enhancers and retardants offers valuable insights.
- Understanding structure-activity relationships is key to developing effective topical agents.
- Safer alternatives for drug delivery and topical formulations are being actively sought.