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Phosphatases and kinases delivered to the host cell by bacterial pathogens
R DeVinney1, O Steele-Mortimer, B B Finlay
1Biotechnology Laboratory, University of British Columbia, Vancouver British Columbia, Canada V6T 1Z3.
Trends in Microbiology
|January 19, 2000
Abstract:
The gram-negative type III secretion pathway translocates bacterial proteins directly into eukaryotic host cells, thus allowing a pathogen to interfere directly with host signalling pathways. Protein and inositol phosphatases and protein kinases have been identified as delivered effectors in three bacterial pathogens, Salmonella, Shigella and Yersinia, and it is expected that several more such type III effectors will be found.