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Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine
V Boudou1, J L Imbach, G Gosselin
1Laboratoire de Chimie Bioorganique, UMR C.N.R.S. 5625, Université de Montpellier II, Sciences et Techniques du Languedoc, France.
Abstract:
For the first time, the stereospecific synthesis of 9-(beta-L-arabinofuranosyl) adenine was carried out. Unfortunately, and unlike its "natural" D-counterpart Vidarabine, this L-enantiomer did not show significant activity when evaluated against a broad range of viruses.
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