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Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration
K Ikemoto1, A Nishimura, N Okado
1Department of Anatomy, School of Medicine, Fujita Heath University, Toyoake, Aichi 470-1192, Japan. kikemoto@fujita-hu.ac.jp
Brain Research
|January 21, 2000
Abstract:
We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in the human ventral tegmental area (VTA) using by a recently raised antibody against 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A receptors at the level of their originating nuclei.