Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ocular cicatricial pemphigoid].

S Giuri1

  • 1Spitalul Municipal Timişoara.

Oftalmologia (Bucharest, Romania : 1990)
|January 21, 2000
PubMed
Summary
This summary is machine-generated.

Scarring ocular pemphigoid is an autoimmune disease causing conjunctival scarring and vision loss. Research highlights its immunopathology, involving antigen-antibody reactions and fibroblast activation, leading to fibrosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifocal choroidal metastases from thyroid carcinoma: a case report.

Chirurgia (Bucharest, Romania : 1990)·2013
Same author

[Ocular decompression retinopathy after combined deep sclerectomy and trabeculotomy].

Klinische Monatsblatter fur Augenheilkunde·2012
Same author

[Combined hamartoma of the retina and retinal pigment epithelium].

Journal francais d'ophtalmologie·2004
Same author

[Conjunctival-palpebral Kaposi's angiosarcoma: report of a case].

Journal francais d'ophtalmologie·2003
Same author

[Cutaneous palpebral anthrax].

Journal francais d'ophtalmologie·2003
Same author

[Myelinated nerve fibers associated with juxtapapillary haemorrhages].

Oftalmologia (Bucharest, Romania : 1990)·2002
Same journal

[Macular serpiginous choroiditis complicated by macular hole].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Therapeutic approach in persistent diabetic macular edema].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Preliminary results of treatment with aflibercept].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

MANAGEMENT OF DIABETIC RETINOPATHY, PREVALENCE AND CLINICAL CLASSIFICATION.

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Changes in intraocular pressure depending on posture].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Treatment for penetrating wound caused by metallic intraocular foreign body].

Oftalmologia (Bucharest, Romania : 1990)·2015
See all related articles

Area of Science:

  • Ophthalmology
  • Immunology
  • Dermatology

Context:

  • Ocular pemphigoid is an acquired oculo-muco-cutaneous bullous dermatosis.
  • It presents with acute conjunctival bullae evolving into ulcerous lesions.
  • Chronic stages involve conjunctivitis, corneal damage, dry eye, and eyelid abnormalities.

Purpose:

  • To review the immunopathological mechanisms of scarring ocular pemphigoid.
  • To identify key antigenic structures involved in the disease process.
  • To elucidate the roles of immunoregulating cells and fibroblasts.

Summary:

  • Scarring ocular pemphigoid involves a type II hypersensitivity reaction at the conjunctival epithelium basement membrane.
  • Antigenic targets include bullous pemphigoid antigen-2, laminin 5-6, and beta 4 integrin.

Related Experiment Videos

  • Activated fibroblasts drive subepithelial fibrosis in the chronic stage.

    • Impact:

    • Understanding the immunopathology aids in developing targeted therapies for ocular pemphigoid.
    • Identifying antigenic structures can lead to improved diagnostic tools.
    • Elucidating the role of fibroblasts offers insights into preventing or reversing conjunctival scarring.