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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
[The interrelation of microbial ecosystems and human immunity]
E A Fedorovskaia1, L N Nemirovskaia
1Kyiv Scientific-Research Institute of Hematology and Blood Transfusion, Ministry of Public Health of Ukraine.
Abstract:
An analytical survey of literature on the problem of the study of interrelations between the immune status of the organism and microbial ecology of a man is presented. The criteria which characterize normal flora of human organism varying in the process of evolutionary adaptation, interaction with microorganism and response of the immune system, its participation in formation of protective functions of the organism are considered. It is shown that the proceeding character and the finite result of different infectious processes depend on the state of the organism immune system. A possibility of correction of certain immunological indices with the help of representatives of normal microflora has been considered. A conclusion has been made on the necessity to solve the problem of infectious diseases and complications in a complex of microbiological and immunological investigations.
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