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Updated: Oct 18, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
[The initial tone of arteries determines the magnitude of depressor responses caused by nitroglycerin]
L I Osadchiĭ1, T V Balueva, I V Sergeev
1I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Abstract:
The correlation analysis revealed a direct (within the range 80 to 120 mm Hg) further transforming into a reverse (within the range 121 to 160 mm Hg) dependence of the blood pressure depressor shifts on the initial mean arterial pressure in anaesthetised rats. Within the physiological range of arterial pressure (70 to 130 mm Hg) there is no difference in responses to nitro-glycerine from their initial values. The mechanisms of dependence of the systemic vascular responses on initial tone of arterial vessels, are discussed.
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