[Distribution of recombinant pro-urokinase in the rabbit blocked carotid artery]

Distribution of recombinant pro-urokinase (PRU) in segments of blocked carotid arteries of rabbits was measured in 10, 20 and 30 minutes after i.v. administration of the RPU. Concentration of the latter in the bloodstream taken as 100% on the 3rd minute, after the infusion decreased to 42% in 10 min., 24% in 20 min., and 13% in 30 min. The RPU concentration decreased to 2% at the artery clamp point, to 20% at 10-15 cm from the clamp point, and remained constant for 10-30 min. A thrombolytic agent accumulated at the dead-end of the blocked artery, was not subject to rapid clearance in contrast to circulating pro-urokinase.