Related Experiment Videos
[Prion phenomenon in medicine and biology]
M D Ter-Avanesian1, I E Shitikova, I A Zavalishin
1Cardiological Research-Industrial Complex, Moscow, Russia.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|January 22, 2000
Abstract:
The data obtained suggest that the fatal changes in brain tissue associated with the prion diseases, are initiated by a conformational rearrangement of constitutively expressed cellular protein PrP. Possible mechanisms of such a conversion of this protein are discussed. Existence of the proteins with the prion properties in low eukaryotes may determine the unusual mechanisms of the "protein" inheritance. A new experimental model for studying the proteins with the prion properties in the yeast Saccharomyces cerevisiae, is described.