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Effect of mitomycin C for combined trabeculectomy and phacoemulsification
1Department of Ophthalmology, Taipei Veterans General Hospital, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|January 25, 2000
Summary
Intraoperative mitomycin C (MMC) in combined cataract and glaucoma surgery significantly reduced intraocular pressure and glaucoma medication dependence. This safe approach improved surgical success rates without major complications.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Management
Background:
- Coexisting glaucoma and cataract present a surgical challenge.
- Trabeculectomy combined with phacoemulsification (phacotrab) is a common surgical approach.
- Evaluating adjuncts to improve phacotrab outcomes is crucial.
Purpose of the Study:
- To assess the efficacy and safety of intraoperative mitomycin C (MMC) during phacotrab surgery.
- To compare outcomes between patients receiving MMC and a control group.
Main Methods:
- Retrospective chart review of patients undergoing phacotrab.
- Comparison of pre- and postoperative intraocular pressure (IOP), medication use, and visual acuity.
- Kaplan-Meier survival analysis for surgical success rates.
Main Results:
- MMC group showed significantly lower mean IOP at multiple follow-up points compared to the control group.
- Both groups experienced significant visual acuity improvement.
- Mean glaucoma medication use decreased substantially in the MMC group (0.18 vs. 0.72).
- One-year complete success rate was significantly higher in the MMC group.
Conclusions:
- Intraoperative MMC enhances postoperative filtration in phacotrab.
- MMC reduces the need for glaucoma medications post-surgery.
- No significant adverse effects were noted with MMC application.