[Urticarial vasculitis--a syndrome with low complement levels and secondary glomerulopathy]

Area of Science:

• Rheumatology
• Nephrology
• Dermatology

Context:

• A 41-year-old female presented with urticarial skin lesions, arthralgia, fatigue, and edema.
• Initial laboratory results revealed hypocomplementemia, proteinuria, microhematuria, and cylindruria.

Purpose:

• To report a case of co-occurring leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis.
• To evaluate the therapeutic response to Dapsone and corticosteroids in this patient.

Summary:

• Histopathology confirmed leukocytoclastic vasculitis in skin biopsy and mesangioproliferative glomerulonephritis in kidney biopsy.
• Dapsone administration led to regression of skin lesions; however, hypocomplementemia and proteinuria persisted despite corticosteroid therapy.

Impact:

• This case underscores the complex interplay between cutaneous and renal manifestations in vasculitic syndromes.
• It suggests Dapsone as a potential treatment for skin symptoms, while highlighting the challenges in achieving complete remission of renal involvement.