Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How does positive end-expiratory pressure decrease pulmonary CO2 elimination in anesthetized patients?

J L Johnson1, P H Breen

  • 1Department of Anesthesiology, University of California at Irvine, UCI Medical Center, Orange 92868, USA.

Respiration Physiology
|January 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Through the haze of cigarettes: teenage girls' stories about cigarette addiction.

Qualitative health research·2001
Same author

Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Retinal photoreceptors and visual pigments in Boa constrictor imperator.

The Journal of experimental zoology·2001
Same author

Evaluation of suspected tuberculous pleurisy: clinical and diagnostic findings in HIV-1-positive and HIV-negative adults in Uganda.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2001
Same author

Intraperitoneal blood exacerbates the remote inflammatory response to murine peritonitis.

The Journal of trauma·2001
Same author

Dose-escalated cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) chemotherapy for patients with diffuse lymphoma: Cancer and Leukemia Group B studies 8852 and 8854.

Cancer·2001
Same journal

Braking of expiratory airflow in obese pigs during wakefulness and sleep.

Respiration physiology·2002
Same journal

Arousal response to hypoxia in newborn mice.

Respiration physiology·2002
Same journal

The oxygen gain of diving insects.

Respiration physiology·2002
Same journal

The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats.

Respiration physiology·2002
Same journal

Active glottal closure during anoxic gasping in lambs.

Respiration physiology·2002
Same journal

Avian intrapulmonary chemoreceptor discharge rate is increased by anion exchange blocker 'DIDS'.

Respiration physiology·2002
See all related articles

Positive end-expiratory pressure (PEEP) initially reduced CO2 exhalation by decreasing tidal volume. Sustained PEEP ventilation led to decreased cardiac output and alveolar ventilation, impacting CO2 delivery and exhalation.

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Positive end-expiratory pressure (PEEP) is crucial in mechanical ventilation.
  • Understanding PEEP's immediate and sustained effects on CO2 elimination is vital for patient management.

Purpose of the Study:

  • To investigate the immediate and sustained impact of PEEP on CO2 volume exhaled per breath (V(CO2,br)) in anesthetized, mechanically ventilated patients.
  • To elucidate the underlying physiological mechanisms affecting CO2 elimination during PEEP.

Main Methods:

  • Application of 10 cm H2O PEEP (PEEP10) in anesthetized, mechanically ventilated patients.
  • Monitoring of exhaled CO2 volume per breath (V(CO2,br)), tidal volume (VT), cardiac output (QT), alveolar ventilation (VA), and end-tidal PCO2 (PET(CO2)).

Related Experiment Videos

Main Results:

  • PEEP10 immediately decreased V(CO2,br) by 96% due to reduced VT.
  • Sustained PEEP10 led to decreased V(CO2,br) from reduced QT and VA.
  • V(CO2,br) recovered to baseline by 20 min as QT increased, despite persistent low VT.

Conclusions:

  • PEEP significantly alters CO2 elimination through complex, time-dependent mechanisms involving VT, QT, and VA.
  • End-tidal PCO2 (PET(CO2)) may not accurately reflect changes in V(CO2,br) during PEEP due to unmeasured exhaled volume.