Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced diarrhoea.

O Chassany1, A Michaux, J F Bergmann

  • 1Internal Medicine Department, Lariboisière University Hospital, Paris, France. olivier.chassany@lrb.ap-hop-paris.fr

Drug Safety
|January 27, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Erratum to "COVID-19 and medical publications: How three articles have influenced the media and public decisions in France" Rev Med Interne 42 (2021) 10.1016/j.revmed.2021.03.010].

La Revue de medecine interne·2021
Same author

[Letter to the editor regarding the article entitled "COVID-19 and medical publications: How three articles have influenced the media and public decisions in France." - Reply].

La Revue de medecine interne·2021
Same author

[COVID-19 and medical publications: How three articles have influenced the media and public decisions in France].

La Revue de medecine interne·2021
Same author

[Characteristics of patients admitted from emergency units in 18 internal medicine departments and organisation of these departments: A cross sectional study from SNFMI (SiFMI study group) in 2015].

La Revue de medecine interne·2020
Same author

[Writing to publish, a barrier to French medical research?]

La Revue de medecine interne·2018
Same author

Once versus twice daily enoxaparin for the initial treatment of acute venous thromboembolism.

Journal of thrombosis and haemostasis : JTH·2017
Same journal

Implementation Aspects of a Medicines Shortage Policy Tool: Evidence from Australia's Serious Scarcity Substitution Instruments.

Drug safety·2026
Same journal

Availability and Communication of Risk Management Strategies for Pregnancy Category X Medicines across Australian Medicine Information Sources.

Drug safety·2026
Same journal

The Bidirectionality of Lawyer Reporting Bias in Disproportionality Analysis.

Drug safety·2026
Same journal

Safety of Biologic and Targeted Synthetic Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis: A Longitudinal Analysis.

Drug safety·2026
Same journal

Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan.

Drug safety·2026
Same journal

Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis.

Drug safety·2026
See all related articles

Diarrhoea is a common adverse drug effect, with over 700 medications implicated. Antimicrobials are a frequent cause, leading to a spectrum of conditions from mild symptoms to severe colitis.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Diarrhoea is a frequent adverse drug event, accounting for approximately 7% of all drug side effects.
  • Over 700 drugs are known to cause diarrhoea, with antimicrobials being the most common culprits.
  • Drug-induced diarrhoea presents a spectrum of severity, ranging from mild to severe conditions like pseudomembranous colitis.

Purpose of the Study:

  • To review the causes, mechanisms, and clinical presentation of drug-induced diarrhoea.
  • To highlight the importance of drug history in diagnosing drug-induced diarrhoea.
  • To discuss the challenges in establishing a temporal relationship between drug use and symptom onset.

Main Methods:

  • Literature review of drugs implicated in causing diarrhoea.

Related Experiment Videos

  • Analysis of pathophysiological mechanisms involved in drug-induced diarrhoea.
  • Discussion of clinical presentation, diagnosis, and management considerations.

    • Main Results:

    • Antimicrobials account for 25% of drug-induced diarrhoea cases.
    • Multiple pathophysiological mechanisms, including osmotic, secretory, and malabsorptive processes, contribute to drug-induced diarrhoea.
    • Both acute and chronic diarrhoea can occur, with onset varying from days to months or years after drug initiation.

    Conclusions:

    • Accurate drug history is crucial for diagnosing drug-induced diarrhoea and avoiding unnecessary investigations.
    • Clinical examination should assess severity indicators like fever, dehydration, and rectal bleeding.
    • Recognizing the diverse range of causative agents and mechanisms is essential for effective patient management.