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[Cytisine pharmacokinetics when used in a transdermal therapeutic system in rabbits]
A K Sariev1, V P Zherdev, S S Sologova
1Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|January 29, 2000
Abstract:
Experimental study of pharmacokinetics of transdermal system with cytisin in rabbits showed a possibility of controlled intake of the drug over a 4-day period. The two stages of attaining the stationary levels of cytisin concentrations are revealed. The first stage lasted during first 24h and the second stage during succeeding 3 days. Using the data on intravenous cytisin injection we found that the stationary concentrations and the rate of cytisin intake in the first stage is twice as large as in the second stage. Thus cytisin can be classed as a short-living drug.